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Some of the prescription drugs and Nexium, Prevacid, Prilosec, Protonix, and Aciphex. Prilosec is a prescription medication indicated for. 4 Starts to neutralize acid on contact Prescription proton pump inhibitors are stronger than the OTC variety. Prilosec decreases stomach acid production which promotes the healing of gastric and duodenal ulcers and other inflamed. They are usually well tolerated by patients but not recommended for long term use. Alot of people including myself, the prescription for Prilosec is cheaper than OTC but yes, same ingredients, same dose. Difference between prescription pepcid and otc pepcid potential conflict of interest in research. A headache is the most common side more Prescription only. Pepcid (famotidine) Prescription and OTC Famotidine is an acid-suppressing agent that may be used to treat a wide range of gastric-acid-related disorders including gastric ulcers, heartburn, and GERD. Acid control does not imply symptom relief. 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