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Prescribed for Anxiety and Stress, Major Depressive Disorder more Prescription only. Both drugs were effective and there were no statistically significant differences between. Pharmacy benefit manager (PBM). This overview summarizes the major and minor side effects and drug interactions of fluoxetine. This study tracks the diffusion of generic fluoxetine after its release in August 2001 within the largest U. 5 out of 10 from a total of 1634 ratings on Drugs. Fluoxetine is an antidepressant medication used to treat conditions like depression, obsessive-compulsive disorder, and panic attacks. Both Prozac and Zoloft belong to the class of medicines called selective serotonin reuptake inhibitors (SSRIs) and are FDA approved to treat depression, OCD (obsessive-compulsive disorder), and panic disorder. The main differences between Prozac and Zoloft are: Prozac is a branded version of fluoxetine and Zoloft is a branded version of sertraline. 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